منابع مشابه
13q deletions in lymphoid malignancies.
Previous studies have indicated that a candidate tumor suppressor gene resides telomeric of the RB1 gene at 13q14, a region that is commonly deleted in B-cell chronic lymphocytic leukemia (B-CLL). In this study, we have evaluated the frequency and minimal region of overlap for 13q deletions in malignant cells from various lymphoid neoplasms. We observed losses at 13q14 in 33/75 (44%) B-CLL case...
متن کاملdel(13q) in myeloid malignancies
Note Chromosomal deletions are among the most common genetic events observed in hematologic malignancies; loss of genetic materiel is regarded as a hallmark of putative tumor suppressor gene localization. Deletions 13q occurs in lymphoid neoplasias: see del(13q) in non-Hodgkin's lymphoma and del(13q) in chronic lymphoproliferative diseases. In myeloid disorders, the most frequently reported del...
متن کاملLymphoid malignancies ARNT unstoppable
(ARNT; also known as hypoxia inducible factor 1-β) is a member of the basic-helix-loop-helix-Per/ARNT/Sim (bHLH-PAS) family of transcription factors. ARNT is a common binding partner in this family and predominantly heterodimerizes with HIF-1α, or the aryl hydrocarbon receptor (AHR), and aids in the recognition of their respective DNA binding sequences [1]. The AHR has been recognized for decad...
متن کاملSubmicroscopic deletions in 5q- associated malignancies.
BACKGROUND AND OBJECTIVES The deletion of the long arm of chromosome 5 is common in myelodysplastic syndromes (MDS) but is not limited to the 5q- syndrome as it is also seen in acute myeloid leukemia (AML), where it is often associated with other karyotypic aberrations. The aim of this study was to investigate whether deletions of known suppressor sequences occur in myeloid malignancies associa...
متن کاملThe Role of Exosomes in Myeloid and Lymphoid Blood Malignancies: A Systematic Review Article
Background and Aim: Blood malignancies, one of the most common cancers in the world, cause a large number of deaths each year. Many inherited and acquired factors are involved in the development of this disease. Exosomes are a very small model of cells that are secreted by most cells in the body under physiological and pathological conditions. On the other hand, they have found a special place ...
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ژورنال
عنوان ژورنال: Blood
سال: 1995
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v86.5.1911.bloodjournal8651911